Recently, the World Health Organisation (WHO) released a report on acute hepatitis in children with an unknown origin. Even though Adenovirus is a hypothesis as being one of the strongly associated reasons for Hepatitis in this report, it is still under investigation. United Kingdom is one of the highly affected countries. PCR analysis has been the first line of diagnosis. Blood sampling, respiratory sampling and stool sampling are being used to collect specimen. Respiratory specimen in a VTM such as the ∑-Virocult® (Viral transport media) and ∑-MM™ inactivation media can be used to collect samples.